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Test Description
The BRCA1-2 Gene Mutation Analysis is a genetic test that detects mutations in the BRCA1 and BRCA2 genes, which are crucial for DNA repair. Mutations in these genes significantly increase the risk of developing breast, ovarian, and other cancers. This test can be performed using a blood or saliva sample, analyzing the genetic material to identify harmful variants that may predispose individuals to these cancers.
Indications of the Test
This test is recommended for individuals with:
– A family history of breast or ovarian cancer, especially if diagnosed at a young age.
– Two or more close relatives with breast cancer or ovarian cancer.
– A male relative with breast cancer.
– Ashkenazi Jewish ancestry with a family history of breast or ovarian cancer.
– Personal history of breast or ovarian cancer, particularly at an early age.
Patient Preparation/Instructions
Before undergoing the test, it is advisable to consult with a genetic counselor to discuss the implications, risks, and benefits of testing. Patients should bring their medical history and any relevant family medical history to the consultation.
Typical Reference Values
The reference values for this test are not standardized as they depend on the presence or absence of mutations. A positive result indicates the presence of a harmful mutation, while a negative result suggests no identified mutations, although it does not eliminate the risk of cancer entirely.
Turnaround Time
The results of the BRCA1-2 Gene Mutation Analysis typically take about 2 to 4 weeks to process, depending on the laboratory and the specific testing methods used.
Order This Test
To order the BRCA1-2 Gene Mutation Analysis, click the ‘Order Test’ button and add it to your cart.
Citations:
[1] https://www.ncbi.nlm.nih.gov/books/NBK470239/
[2] https://www.cancer.gov/about-cancer/causes-prevention/genetics/brca-fact-sheet
[3] https://www.ncbi.nlm.nih.gov/books/NBK1247/
[4] https://medlineplus.gov/ency/patientinstructions/000690.htm
[5] https://www.mayocliniclabs.com/test-catalog/overview/616495
