: 
Test Description
Vitamin B1 Level Test, also known as Thiamine pyrophosphate (TPP) or thiamine diphosphate, is the active form of vitamin B1.
It serves as a crucial cofactor in various enzymatic reactions essential for carbohydrate metabolism and energy production.
TPP is vital for the functioning of several key enzymes, including pyruvate dehydrogenase, alpha-ketoglutarate dehydrogenase, and transketolase, which play significant roles in the tricarboxylic acid (TCA) cycle and the pentose phosphate pathway.
Indications of the Test
Testing for Vitamin B1 Level may be indicated in cases of suspected thiamine deficiency or related disorders, such as:
- Beriberi: A disease caused by thiamine deficiency, leading to cardiovascular and neurological symptoms.
- Wernicke-Korsakoff Syndrome: A severe neurological disorder often associated with alcohol misuse.
- Metabolic Disorders: Conditions that impair energy production and carbohydrate metabolism.
- Neurological Symptoms: Such as ataxia, psychomotor retardation, and dystonia, which may indicate underlying metabolic dysfunction.
Patient Preparation/Instructions
Patients should follow these instructions prior to testing:
- Fasting: It is recommended to fast for at least 8 hours before the test.
- Medication: Inform your healthcare provider about any medications or supplements you are taking, as they may affect TPP levels.
- Dietary Restrictions: Avoid alcohol consumption for at least 24 hours before the test.
Typical Reference Values
Reference values for TPP levels can vary based on laboratory standards but generally fall within the following ranges
- Normal Vitamin B1 Level levels: 10–30 nmol/L
Turnaround Time
The typical turnaround time for results from a TPP test is approximately 3 to 5 working days.
Order Vitamin B1 Level Test in Kenya
To order the Thiamine Pyrophosphate test, please click the ‘Order Test’ button and add it to your cart.
