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Test Description
The Systemic Lupus Erythematosus (SLE) Profile is a specialized blood test designed to detect various autoantibodies associated with SLE, an autoimmune disorder where the immune system mistakenly attacks healthy tissues.
This profile includes tests for antinuclear antibodies (ANA), anti-double-stranded DNA (anti-dsDNA), and other specific autoantibodies that help in diagnosing and monitoring the disease.
It predominantly affects young women, with a female-to-male ratio ranging from 7:1 to 15:1, and typically presents between the ages of 20 and 40.
Clinical Features
SLE can affect multiple organ systems, leading to diverse symptoms, including:
- Constitutional Symptoms: Fatigue, fever, weight changes.
- Musculoskeletal Symptoms: Joint pain (arthralgia), arthritis, myalgia.
- Dermatological Symptoms: Malar rash (butterfly rash), discoid lupus, photosensitivity.
- Renal Involvement: acute or chronic kidney failure, nephritis.
- Neuropsychiatric Manifestations: seizures, psychosis, headaches.
- Pulmonary Symptoms: Pleurisy, pleural effusion, pneumonia.
- Gastrointestinal Issues: Nausea, abdominal pain.
- Cardiac Complications: Pericarditis, myocarditis.
- Hematologic Disorders: Anemia, leukopenia, thrombocytopenia.
Indications of the Test
The SLE Profile is indicated for:
The SLE Profile is indicated for:
- Patients exhibiting symptoms of systemic lupus erythematosus, such as joint pain, fatigue, skin rashes, and organ involvement.
- Monitoring disease activity and response to treatment in diagnosed SLE patients.
- Evaluating potential complications related to lupus, such as kidney involvement or hematological issues.
Patient Preparation/Instructions
- No special preparation is typically required; however, it’s advisable to consult your healthcare provider for any specific instructions.
- Wear short-sleeved clothing or a shirt that can be easily rolled up for blood draw convenience.
Typical Reference Values
Reference values may vary by laboratory but generally include:
- ANA: Negative (<40)
- Anti-dsDNA: Negative (<10 IU/mL)
- Complement Levels (C3 & C4): Normal ranges vary; consult specific lab reference values.
Turnaround Time
Results are usually available within 1 to 3 days, depending on the laboratory’s processing capabilities.
Order This Test
To order the SLE Profile, please click the ‘Order Test’ button and add it to your cart. This will initiate the testing process at our accredited laboratory.
