Creatine Kinase Isoenzymes, Serum

Test Description

The Creatine Kinase Isoenzymes, Serum Test measures the levels of creatine kinase (CK) and its isoenzymes in the blood.

This test helps identify muscle damage, including that of the heart, by differentiating between the three isoenzymes: CK-MM (found in skeletal muscle), CK-MB (found in heart muscle), and CK-BB (found mainly in the brain).

The test is particularly significant in diagnosing myocardial infarction (heart attack) and other conditions related to muscle injury. Elevated levels of specific isoenzymes can indicate damage to particular tissues.

• CK-MM: is primarily found in skeletal muscle; elevated levels suggest muscle injury or stress.
• CK-MB: Mostly located in heart muscle; significant increases indicate myocardial injury.
• CK-BB: Found mainly in the brain; elevated levels may suggest brain injury or conditions affecting the brain.

This test is indicated for:

• Evaluating suspected muscle damage or injury.
• Diagnosing conditions such as myocardial infarction (heart attack) or muscular dystrophy.
• Monitoring the progression of muscle diseases or response to treatment.
• Investigating elevated total CK levels to determine their source.

Methodology

The test involves drawing blood from a vein,  followed by laboratory analysis using techniques such as electrophoresis or photometric assays to quantify the different isoenzymes.

The results help healthcare providers assess the extent and source of tissue damage.

Patient Preparation/Instructions

No specific preparation is required before taking this test. However, patients should inform their healthcare provider about any medications, supplements, or recent physical activities that may affect test results

Normal reference values can vary based on age, sex, and race. Generally:

• Normal Values: Reference ranges vary by age and sex but typically show CK-MM at 100% and CK-MB at 0% in healthy individuals.
• Abnormal Results:
  • Elevated CK-MM indicates skeletal muscle damage.
  • Increased CK-MB suggests cardiac muscle injury, often seen within hours after a heart attack.
  • Elevated CK-BB may point to a brain or lung injury.

Turnaround Time

The typical turnaround time for results is 2 to 6 days, depending on the laboratory processing time.

How To Order This Test In Kenya

To order the Creatine Kinase Isoenzymes, Serum Test, please click the ‘Order Test’ button and add it to your cart.